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Prognostic Impact of Newly Proposed M Descriptors in TNM Classification of Non–Small Cell Lung Cancer  Junghoon Shin, MD, Bhumsuk Keam, MD, PhD, Miso.

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Presentation on theme: "Prognostic Impact of Newly Proposed M Descriptors in TNM Classification of Non–Small Cell Lung Cancer  Junghoon Shin, MD, Bhumsuk Keam, MD, PhD, Miso."— Presentation transcript:

1 Prognostic Impact of Newly Proposed M Descriptors in TNM Classification of Non–Small Cell Lung Cancer  Junghoon Shin, MD, Bhumsuk Keam, MD, PhD, Miso Kim, MD, Young Sik Park, MD, PhD, Tae Min Kim, MD, PhD, Dong-Wan Kim, MD, PhD, Young Whan Kim, MD, PhD, Dae Seog Heo, MD, PhD  Journal of Thoracic Oncology  Volume 12, Issue 3, Pages (March 2017) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Unadjusted Kaplan-Meier survival curves showing the overall survival according to the suggested M categories in the entire (A), double-negative (B), EGFR-mutated (C), and anaplastic lymphoma receptor tyrosine kinase gene (ALK)-translocated (D) cohorts. Log-rank tests and Wilcoxon-Breslow-Gehan tests were used for nonparametric comparisons. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Adjusted survival curves showing the overall survival visualized by pooling the estimated survival curves from multivariate Cox proportional hazards model using marginal distribution of the covariates for the entire cohort (A) and subgroup of patients having received brain magnetic resonance imaging as an initial staging evaluation (B). HR, hazard ratio; 95% CI, 95% confidence interval. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Forest plots of unadjusted hazard ratios (HRs) showing the overall survival for M1b versus M1a (A) and M1c versus M1b (B). HR, hazard ratio; 95% CI, 95% confidence interval; ALK, anaplastic lymphoma receptor tyrosine kinase gene; MRI, magnetic resonance imaging. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

5 Figure 4 Unadjusted Kaplan-Meier survival curves showing the overall survival according to involved sites in the M1a (A) and M1b cohorts (B). Log-rank tests and Wilcoxon-Breslow-Gehan tests were used for nonparametric comparisons. LN, lymph nodes. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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