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Impact of phenylephrine administration on cerebral tissue oxygen saturation and blood volume is modulated by carbon dioxide in anaesthetized patients† 

Published byAgus Hadian Iskandar Modified over 5 years ago

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Presentation on theme: "Impact of phenylephrine administration on cerebral tissue oxygen saturation and blood volume is modulated by carbon dioxide in anaesthetized patients† "— Presentation transcript:

1 Impact of phenylephrine administration on cerebral tissue oxygen saturation and blood volume is modulated by carbon dioxide in anaesthetized patients†  L. Meng, A.W. Gelb, B.S. Alexander, A.E. Cerussi, B.J. Tromberg, Z. Yu, W.W. Mantulin  British Journal of Anaesthesia  Volume 108, Issue 5, Pages (May 2012) DOI: /bja/aes023 Copyright © 2012 The Author(s) Terms and Conditions

2 Fig 1 Study protocol. E′CO2, end-tidal carbon dioxide.
British Journal of Anaesthesia  , DOI: ( /bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

3 Fig 2 Pearson's correlation between changes in cerebral tissue oxygen saturation ( Δ Sct O 2 ) and changes in CBV (ΔCBV). British Journal of Anaesthesia  , DOI: ( /bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

4 Fig 3 (a) Cerebral tissue oxygen saturation ( Sct O 2 ) and (b) CBV changes (Δ) during hypocapnia, normocapnia, and hypercapnia. British Journal of Anaesthesia  , DOI: ( /bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

5 Fig 4 Hypothetical explanation of how phenylephrine treatment induces cerebral autoregulatory vasoconstriction. CSA, cross-sectional area; MAP, mean arterial pressure; CPP, cerebral perfusion pressure; CBF, cerebral blood flow. British Journal of Anaesthesia  , DOI: ( /bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

6 Fig 5 FD-NIRS measurements of THC (top panel), cerebral tissue oxygen saturation (second panel), oxy-haemoglobin concentration (third panel), and deoxy-haemoglobin concentration (bottom panel) during right external carotid artery clamping (a) and right internal carotid artery clamping (b) in a patient with defective collateral circulation through the Circle of Willis. Note that the time scales (s) are different between (a) and (b). (Courtesy of Fady T. Charbel, MD, FACS.) British Journal of Anaesthesia  , DOI: ( /bja/aes023) Copyright © 2012 The Author(s) Terms and Conditions

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