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Independent Control of Aging and Axon Regeneration

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Presentation on theme: "Independent Control of Aging and Axon Regeneration"— Presentation transcript:

1 Independent Control of Aging and Axon Regeneration
Stephane Belin, Michael Norsworthy, Zhigang He  Cell Metabolism  Volume 19, Issue 3, Pages (March 2014) DOI: /j.cmet Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 The Signaling Pathways Regulating Life Span and Regeneration
Both daf-2/insulin receptor and daf-18/PTEN-mTOR impact animals’ life spans. However, daf-2/insulin receptor inhibits age-dependent axon regeneration via a daf-16/FOXO-DLK pathway, and daf-18/PTEN-mTOR regulates axon regeneration in both young and aging animals. The interactions of these pathways in coordinating neuronal responses to axonal insults remain unknown. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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