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Fig. 2. GDF15 crystal structure and enabled design of GDF15 molecules.

Published byFarida Iskandar Modified over 5 years ago

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Presentation on theme: "Fig. 2. GDF15 crystal structure and enabled design of GDF15 molecules."— Presentation transcript:

1 Fig. 2. GDF15 crystal structure and enabled design of GDF15 molecules.
GDF15 crystal structure and enabled design of GDF15 molecules. (A) Side view and (B) top view of the crystal structure of GDF15 dimer at 2.3 Å with individual subunits shown in gold and cyan. The N terminus and C terminus are highlighted by dotted spheres. (C) Close-up view of the C terminus of GDF15. One GDF15 monomer is shown in beige surface representation. The C-terminal residue Ile112 of the other monomer is shown in stick representation. The van der Waals radius of Ile112 is shown as dotted spheres. (D) Summary of the ED50 of GDF15 fusion molecules. DhFc, hinge-deleted Fc fragment; CpmFc, charge-paired mutant of Fc fragment; DhCpmFc, hinge-deleted charge-paired Fc fragment; ScFc, single-chain Fc fragment. Yumei Xiong et al., Sci Transl Med 2017;9:eaan8732 Published by AAAS

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