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PHIPing Out: A Genetic Basis for Tumor Ulceration

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Presentation on theme: "PHIPing Out: A Genetic Basis for Tumor Ulceration"— Presentation transcript:

1 PHIPing Out: A Genetic Basis for Tumor Ulceration
Jack L. Arbiser  Journal of Investigative Dermatology  Volume 134, Issue 3, Pages (March 2014) DOI: /jid Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Convergence of pathways in melanoma leads to NF-κB activation and glycolysis. The major pathways in melanoma, Braf mutation, Nras mutation, and PHIP mutation all potentially involve a superoxide/Akt/NF-κB pathway (reactive oxygen–driven pathway) to result in glycolysis, NF-κB activation, and ulceration through angiopoietin-2 expression. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Journal of Investigative Dermatology 2014 134, 600-602DOI: (10
Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions


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