1. Hunting Down the HIV-1 Reservoir: A Starring Role for Antibodies?
Hugo Mouquet 
Immunity 
Volume 46, Issue 4, Pages (April 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 Antibody-Mediated Long-Term HIV-1 Remission
Contrary to ART, an early treatment cycle including a mixture of two bNAbs for SHIV-infected macaques can lead to sustained virological control regardless of the challenge route (intrarectal or intravenous). CD8+ T cell responses induced by bNAb immunotherapy are responsible for viraemia suppression in animals controlling the infection (Nishimura et al., 2017). A theoretical scenario that can be envisioned in HIV-1-infected humans is that prolonged ART combined with bNAb infusions started early in the acute phase could augment the chances of reaching a PTC phenotype after ART is stopped.
Immunity  , DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions