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This Month in Gastroenterology

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Presentation on theme: "This Month in Gastroenterology"— Presentation transcript:

1 This Month in Gastroenterology
Laura Harrell, Eugene B. Chang  Gastroenterology  Volume 130, Issue 1, Pages 1-3 (January 2006) DOI: /j.gastro Copyright © 2006 American Gastroenterological Association Terms and Conditions

2 Figure 1 The anatomical location of composite fMRI activity associated with subliminal rectal distention in 10 diarrhea-predominant female IBS patients is shown. fMRI activity can be characterized to exist in 5 broad cortical regions: the sensory/motor, the parietal/occipital, the cingulate gyrus, the prefrontal, and the insula cortices. Gastroenterology  , 1-3DOI: ( /j.gastro ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

3 Figure 2 Proposed model of MMP-mediated epithelial immune activation through PBP and CXCL7. Intestinal epithelial cells under proinflammatory conditions synthesize and secrete PBP, which in itself has no chemotactic activity. However, when MMPs are released by activated subepithelial myofibroblasts epithelial PBP is processed into chemotactically active CXCL7, resulting in the recruitment of neutrophils to the site of inflammation. Gastroenterology  , 1-3DOI: ( /j.gastro ) Copyright © 2006 American Gastroenterological Association Terms and Conditions


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