1. Pradaxa Jeopardy
Copyright 2001

2. Single Jeopardy
To Clot or
Not to
Clot….
Are you
Afib-ing
Me?
Pharmaco-
Kinetics are
Phun
You Really
Want
Rat Poison?
$100
$100
$100
$100
$200
$200
$200
$200
End of
Round
$300
$300
$300
$300
$400
$400
$400
$400
$500
$500
$500
$500

4. What is the scientific term for the platelets?
$100
What is the scientific term for the platelets?
TIMES UP
Answer

5. $100
Thrombocytes
Single Jeopardy
Repeat Question

6. $200 What is the name of the protein involved in
converting fibrinogen to fibrin to form
a clot?
TIMES UP
Answer

7. $200
Thrombin
Single Jeopardy
Repeat Question

8. Name the four clotting factors with which
$300
Name the four clotting factors with which
thrombin is involved.
TIMES UP
Answer

9. $300
Factors 5, 8, 11, 13
Single Jeopardy
Repeat Question

10. $400 What is the name of the glycoproteins that
are released from damaged cells and
cause platelet adhesion & activation?
TIMES UP
Answer

11. $400
Von Willebrand factor
Single Jeopardy
Repeat Question

12. $500 What two chemicals interact with each
other to create the complex that
activates thrombin formation?
TIMES UP
Answer

13. $500
Tissue Factor & Factor 8
Single Jeopardy
Repeat Question

14. $100 What phenomenon occurs in NVAF that
results in heart depolarizations that
are out of sequence?
Answer

15. Afterdepolarizations
$100
Afterdepolarizations
Single Jeopardy
Repeat Question

16. $200 Which type of heart remodeling involves an
alteration of the movement of ions?
TIMES UP
Answer

17. $200
Electrical
Single Jeopardy
Repeat Question

18. $300 State the two-word description of the pattern
of heart rhythm seen in an NVAF patient
TIMES UP
Answer

19. $300
Irregularly regular
Single Jeopardy
Repeat Question

20. Double the efficacy, double the points
Daily Double
Double the efficacy, double the points
Question

21. $400 Name five clinical conditions associated
with stroke in an NVAF patient
TIMES UP
Answer

22. $400 Prior stroke or TIA Diabetes Hypertension Age History of CHF
Single Jeopardy
Repeat Question

23. Name the six subtypes of NVAF.
$500
Name the six subtypes of NVAF.
TIMES UP
Answer

24. $500 Recurrent Paroxysmal Persistent Permanent Lone Atrial Secondary
Single Jeopardy
Repeat Question

25. Name the category of anticoagulants to which Pradaxa belongs.
$100
Name the category of anticoagulants
to which Pradaxa belongs.
TIMES UP
Answer

26. Direct Thrombin Inhibitors
$100
Direct Thrombin Inhibitors
Single Jeopardy
Repeat Question

27. Peak blood levels of Pradaxa are reached
$200
Peak blood levels of Pradaxa are reached
within ___ hours.
TIMES UP
Answer

28. $200
two
Single Jeopardy
Repeat Question

29. The terminal half-life of Pradaxa is
$300
The terminal half-life of Pradaxa is
______ hours
TIMES UP
Answer

30. $300
12-17
Single Jeopardy
Repeat Question

31. Daily Double
Question

32. How is Pradaxa eliminated from the body?
$400
How is Pradaxa eliminated from the body?
Give site and %.
TIMES UP
Answer

33. $400
80% from the kidneys
Single Jeopardy
Repeat Question

34. $500 Name the study that identified a safe dose
of Pradaxa in patients with NVAF.
TIMES UP
Answer

35. $500
The PETRO study
Single Jeopardy
Repeat Question

36. What is warfarin’s mechanism of action?
$100
What is warfarin’s mechanism of action?
TIMES UP
Answer

37. $100
Vitamin K antagonist
Single Jeopardy
Repeat Question

38. What is the GI bleed risk of Pradaxa
$200
What is the GI bleed risk of Pradaxa
compared to warfarin?
TIMES UP
Answer

39. $200
1.6% vs 1.1%
Single Jeopardy
Repeat Question

40. $300 According to the RE-LY trial, how much
better was Pradaxa’s risk reduction
compared to warfarin for the
primary efficacy endpoint?
TIMES UP
Answer

41. $300
35%
Single Jeopardy
Repeat Question

42. What was Pradaxa’s risk reduction for hemorrhagic stroke vs warfarin?
$400
What was Pradaxa’s risk reduction for
hemorrhagic stroke vs warfarin?
TIMES UP
Answer

43. $400
74%
Single Jeopardy
Repeat Question

44. Besides its use in NVAF, name one other indication for warfarin.
$500
Besides its use in NVAF, name one other
indication for warfarin.
TIMES UP
Answer

45. $500 Venous thrombosis Pulmonary embolism
Mechanical valve replacements
Reducing risk of death, recurrent
MI, stroke or systemic embolism after MI
Single Jeopardy
Repeat Question

46. State the complete inclusion criteria for patients in the RE-LY study.
FINAL JEOPARDY
State the complete inclusion criteria for
patients in the RE-LY study.
Answer

47. Diagnosis of atrial fibrillation documented
on ECG or within 6 months previous and
at least one of the following:
Previous stroke or TIA;
LVEF of less than 40%
Class II or higher heart failure w/in 6 mths
Age of at least 75 years
Age of diabetes, hypertension, or CAD