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Impact of high serum progesterone during the late follicular phase on IVF outcome  Charlotte Sonigo, Géraldine Dray, Clémence Roche, Isabelle Cédrin-Durnerin,

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Presentation on theme: "Impact of high serum progesterone during the late follicular phase on IVF outcome  Charlotte Sonigo, Géraldine Dray, Clémence Roche, Isabelle Cédrin-Durnerin,"— Presentation transcript:

1 Impact of high serum progesterone during the late follicular phase on IVF outcome 
Charlotte Sonigo, Géraldine Dray, Clémence Roche, Isabelle Cédrin-Durnerin, Jean-Noel Hugues  Reproductive BioMedicine Online  Volume 29, Issue 2, Pages (August 2014) DOI: /j.rbmo Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

2 Figure 1 The different steps of steroidogenesis in humans.
Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

3 Figure 2 Steroidogenesis during follicular phase. (A) During the early follicular phase, LH acts exclusively on theca cells to stimulate 3βHSD type 2 to convert pregnenolone to progesterone and the CYP 17 enzymic complex to activate the conversion of progesterone or pregnenolone to 17 hydroxylated products. (B) During the late follicular phase, LH acts not only on theca cells but also on granulosa cells where LH receptors are strongly expressed in mature follicles. Reproductive BioMedicine Online  , DOI: ( /j.rbmo ) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

4 Reproductive BioMedicine Online 2014 29, 177-186DOI: (10. 1016/j. rbmo
Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions


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