1. Knotless Tissue Repair and Attachment Devices
1250 S. Tamiami Trail Suite 303 Sarasota, FL US

2. Knotless Tissue Repair and Attachment Devices
$5,000,000 Series “A” Offering Contingent on FDA Approval 510k Filed-Completed First Review Providing Requested Additional Information R
Knotless Tissue Repair and Attachment Devices
Patent #

3. What Does Ziptek Make? Patented!
The ZipE® is a surgical button or “capture” that slides along a suture with protuberances in a forward direction and is prevented from moving backwards along its path, similar to a Zip-Tie, and is the backbone of the technology platform. It is a knotless tissue repair device used for tissue-to-tissue and tissue-to-bone repair.
The U.S. Soft Tissue Repair Market, per annum, is about $2-3 billion.
Patented!
Initially focused on Rotator Cuff Repair Market
There are over 21 other Indications For Use(IFUs) filed with the FDA application

5. Most Common form of failure is rip through
Traditional Suture vs ZipE® Repair
The Advantage
ZipE® Tissue
Repair
Traditional Tissue
Repair
Knotted or knotless
Most Common form of failure is rip through
Increased contact surface area for lower
failure rates
Prevents rip through
Like Tying a Bow Like a Carpet Floor Tack

6. The ® Advantage! Suture Ripthrough-Traditional Repair
ZipE® Capture Stabilization
All devices on the market suffer from high rates of failure due to rip through. This video shows how the ZipE® stabilizes the tissue, helps prevent this form of failure, and creates increased contact surface area allowing for improved tissue healing. The rate of non-healing and re-tears can be higher than 60%, or about a $300 million/year U.S. expenditure on failed rotator cuff surgery.

7. Patents 7 Patents Issued 3 More Expected Within 6-12 Months
11 Countries plus E.U.(28)- Patentable Material Filed
2 Foreign Patents Have Already Been Issued
Patent #

8. Patent Pending-Patentable WIPO*
-Driver*
-Method*
-Screw*
Multi-Purpose Driver
Capture Holster
Capture Pusher
Our other patents open up additional realms for further applications -special screws
-driver
*Deemed patentable by WIPO-filed in 11 countries plus E.U.(28)

9. ZipE® Surgical Procedure Steps
Fast!
Secure
Repeatable
Consistent

10. ZipE® Surgical Procedure Steps

11. Testing Test Certification Status Biocompatibility
21 CFR Part 58 Compliance
Good Laboratory Practice for Nonclinical / Lab Studies
ISO tests
Passed
Performance testing
Biomechanical- static and cyclic loading
USP 39-NF 33:2016 <881> Tensile Strength
Degradation Studies
ASTM F1635
Sterilization Validation
ISO 11135
EO Residuals
Shelf life -post accelerated aging
ASTM F1980
Passed*
ASTM 2096 – 11
Seal Package Validation
ISO :2006
ASTM F88/F88M-15
Finalizing bubble burst testing
Specific testing categories that have been performed and passed include:
*1 year passed

12. William F Bennett MD Orthopedic Surgeon Founder Bio
20-plus years experience in this domain
Intellectual Property-knotless devices
Driver of knotless market evolution
Early arthroscopic rotator cuff repair specialist
~Earliest to file a knotless device patent
Numerous issued patents in this domain
Numerous publications in this domain
2nd and 3rd generation products in development
Preparing for “Biologics” integration
Principal Ziptek Mexico Sa De Cv! Biomedical Engineers
Ziptek Mexico Sa De Cv has won multiple Grants enabling Ziptek LLC to accelerate further product design
Dr. Bennett CV
Hermosillo, Sonora, Mexico

13. Concept to Market 20 years
510k FDA Application
Filed! Aug 2016
New Patents
Issued
1995
2000
2010
2020
2017
New patents
Filed
Ziptek
Funded
2014 R
3 PATENTS Issued
Decision To
Commercialize
2009
First business plan
Ziptek LLC
Incorporated
2012
Market Entry!
FDA Approval
Expected late 1st
Or early 2nd quarter
Capture idea born!
First knotless Patent
Application filed, May 1995
Testing Completed Passed
Biocompatibility
Performance Testing
Degradation Studies
Package Validation
Sterilization Validation
EO Residuals
Shelf Life
Trademark accepted
By the FDA-2016
Negotiated
Operational Agreement with Mexican
Biomed engineer, PhD and partner
2010
According to data from the Journal of the American Academy of Orthopedic Surgeons, with FDA approval In January, 2017,
Ziptek will have achieved this milestone using 1/30th of average cost to get approval!!

14. Why Invest? ~2-3 Billion per year- U.S. Soft Tissue Repair Market
U.S. Rotator Cuff ~500,000, Ankle Ligament- ~1,000,000 cases/year
ZipE® is a Disruptive technology platform- only device that prevents rip through which is the highest failure mode for all other devices on the market multiple Indications For Use (IFU~21)
-multiple device pipelines
-multiple surgical disciplines
ZipE® Engineering is One of a Kind! 2.5:1 force ratio!

15. Why Invest?
Patent language covers indications outside of orthopedics - -Patentable material filed in 11 Countries plus E.U.(28)
Ziptek Mexico Sa De Cv- Mexican support company
-Founder William F Bennett MD- Sonora, Mexico
Ziptek LLC is positioning itself for rapid growth- by introducing ZipE® to Surgeons through ongoing orthopedic research projects
-Florida Orthopedic Training program- contact area cadaveric study -Mexico’s Federal Orthopedic Program– sheep model healing
-Colorado Orthopedic Training and Research Foundation- sheep model vascularity
-European Groups-Worldwide Distribution network interested-ongoing

16. Why Invest in Us?
AAOS 2016 Annual Meeting Distributor Sample of Who wants to be Notified with FDA Approval

17. Orthopedic Sports Surgeon
Why Invest in Us?
Testimonial Sample
USA
Dubai
Canada
William. D. Murrell, Jr., M.D.
Shoulder and Sports
Surgeon
I have worked with Bill on worldwide distribution planning for the Ziptek implant. In my opinion, also being a primary shoulder surgeon, the device should revolutionize the
care of rotator cuff repair.
Consultant Orthopaedic Sports Medicine
DHBMC
Dubai, United Arab Emirates
Marcos V. Masson M.D.
Shoulder Surgeon
I have looked at the patents, the prototypes and the technique-the key is simplicity- with the avoidance of knot tying more surgeons will adopt the technique.
Don Johnson M.D.
Orthopedic Sports Surgeon
I have reviewed the product that Bill has been developing the past couple of years, and feel that it has great potential to be a significant improvement in the knotless anchor sphere.
Director, Sports Medicine Clinic Carleton University (colleague)

18. New Funding Round
Rapid growth to access national and international markets
Buildout of Infrastructure to include a sales force and inventory
Introduce to Surgeons-
at meetings and by exhibiting
by sponsorships and training
Prosecuting ongoing patent and foreign regulatory approval
“Work-Around” patent applications filed- grab majority Global
control of this domain
$30,000,000 30 20 10
2017
2018
2019
2020
Revenue in Millions(US Dollars)

19. $5,000,000 Series “A” Offering Filed to FDA August 2016 Completed First Review Providing Requested Additional Information
*FDA Approval Contingency
*With Ziptek FDA Approval
this milestone will be achieved at ~1/30th
the average cost for other 510k approvals
Thank You!

20. Ziptek Surgical Brochure
Investor Intro Letter
Ziptek Surgical Brochure
Management