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Association between (CCTTT)n repeat polymorphism in NOS2 promoter and asthma exacerbations  Keita Hirai, PhD, Toshihiro Shirai, MD, PhD, Masayuki Suzuki,

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Presentation on theme: "Association between (CCTTT)n repeat polymorphism in NOS2 promoter and asthma exacerbations  Keita Hirai, PhD, Toshihiro Shirai, MD, PhD, Masayuki Suzuki,"— Presentation transcript:

1 Association between (CCTTT)n repeat polymorphism in NOS2 promoter and asthma exacerbations 
Keita Hirai, PhD, Toshihiro Shirai, MD, PhD, Masayuki Suzuki, BSc, Tatsuki Shimomura, BSc, Kunihiko Itoh, PhD  Journal of Allergy and Clinical Immunology  Volume 142, Issue 2, Pages e3 (August 2018) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 The relationship between the CCTTT repeat polymorphism and NOS2 mRNA expression levels. A, The allele frequency of CCTTT repeat polymorphism in NOS2. B, The smoothing line for changes in NOS2 mRNA expression levels by the sum of CCTTT repeat number. C, NOS2 mRNA expression levels across the shorter allele. D, NOS2 mRNA expression levels across the longer allele. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 The relationship between the CCTTT repeat polymorphism and NOS2 mRNA expression levels. A and B, The smoothing line for changes in NOS2 mRNA expression levels by CCTTT repeat number of shorter allele (Fig E1, A) or CCTTT repeat number of longer allele (Fig E1, B). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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