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Volume 146, Issue 2, Pages e6 (February 2014)

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1 Volume 146, Issue 2, Pages 430-441.e6 (February 2014)
Simeprevir Increases Rate of Sustained Virologic Response Among Treatment- Experienced Patients With HCV Genotype-1 Infection: A Phase IIb Trial  Stefan Zeuzem, Thomas Berg, Edward Gane, Peter Ferenci, Graham R. Foster, Michael W. Fried, Christophe Hezode, Gideon M. Hirschfield, Ira Jacobson, Igor Nikitin, Paul J. Pockros, Fred Poordad, Jane Scott, Oliver Lenz, Monika Peeters, Vanitha Sekar, Goedele De Smedt, Rekha Sinha, Maria Beumont-Mauviel  Gastroenterology  Volume 146, Issue 2, Pages e6 (February 2014) DOI: /j.gastro Copyright © 2014 AGA Institute Terms and Conditions

2 Figure 1 SVR24 by prior response to PegIFN/RBV and HCV genotype-1 subtype. aDuration groups pooled. SMV, simeprevir. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

3 Figure 2 SVR24 by prior response to PegIFN/RBV and METAVIR score. aDuration groups pooled. SMV, simeprevir. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

4 Figure 3 Treatment outcomes and reasons for not achieving SVR24. SMV, simeprevir. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

5 Supplementary Figure 1 Study design.
Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

6 Supplementary Figure 2 CONSORT flow diagram.
Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

7 Supplementary Figure 3 SVR24 according to IL28B (rs12979860) genotype.
Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

8 Supplementary Figure 4 Mean (A) total, (B) direct, and (C) indirect bilirubin during the 72-week study period. (D) Mean total bilirubin values for patients with METAVIR score F4. Horizontal lines in each figure represent the upper and lower limits of normal, respectively. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions


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