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Paul D. Thompson, MD, John Rubino, MD, Matthew J. Janik, MD, Diane E

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Presentation on theme: "Paul D. Thompson, MD, John Rubino, MD, Matthew J. Janik, MD, Diane E"— Presentation transcript:

1 Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance 
Paul D. Thompson, MD, John Rubino, MD, Matthew J. Janik, MD, Diane E. MacDougall, MS, Scott J. McBride, MA, Janice R. Margulies, MS, Roger S. Newton, PhD  Journal of Clinical Lipidology  Volume 9, Issue 3, Pages (May 2015) DOI: /j.jacl Copyright © 2015 National Lipid Association Terms and Conditions

2 Figure 1 Study design. PBO, placebo.
Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

3 Figure 2 Patient disposition. Asterisk, based on low-density lipoprotein cholesterol (LDL-C). mITT, modified intent to treat. Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

4 Figure 3 Least squares (LS) mean percent change from baseline to week 8 in calculated low-density lipoprotein cholesterol (LDL-C) (primary end point). Asterisk, P < .0001 based on analysis of covariance model with effect of treatment and baseline value as a covariate. CI, confidence interval. Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

5 Figure 4 Changes from baseline in low-density lipoprotein cholesterol (LDL-C), non–high-density lipoprotein cholesterol (HDL-C), and total cholesterol by treatment group. Analysis is based on the completer population for each time point. Asterisk, P ≤ .0001 based on analysis of covariance model with effect of treatment and baseline value as a covariate. PBO, placebo. Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

6 Figure 5 Patients achieving National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) low-density lipoprotein cholesterol (LDL-C) goal at the end of the study. Analysis included patients not at NCEP ATP-III goal at baseline (n = 34, ETC-1002; n = 17, placebo). Missing values at week 8 were imputed using the last-observation-carried-forward procedure. Asterisk, P < .0001 compared with placebo at week 8 (end of study) based on the Fisher exact test. Journal of Clinical Lipidology 2015 9, DOI: ( /j.jacl ) Copyright © 2015 National Lipid Association Terms and Conditions

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