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Acquired von Willebrand Syndrome in Continuous-Flow Ventricular Assist Device Recipients  Sheri Crow, MD, Dong Chen, MD, PhD, Carmelo Milano, MD, William.

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Presentation on theme: "Acquired von Willebrand Syndrome in Continuous-Flow Ventricular Assist Device Recipients  Sheri Crow, MD, Dong Chen, MD, PhD, Carmelo Milano, MD, William."— Presentation transcript:

1 Acquired von Willebrand Syndrome in Continuous-Flow Ventricular Assist Device Recipients 
Sheri Crow, MD, Dong Chen, MD, PhD, Carmelo Milano, MD, William Thomas, PhD, Lyle Joyce, MD, PhD, Valentino Piacentino, MD, PhD, Riti Sharma, MD, Jogin Wu, PhD, Gowthami Arepally, MD, Dawn Bowles, PhD, Joseph Rogers, MD, Nestor Villamizar-Ortiz, MD  The Annals of Thoracic Surgery  Volume 90, Issue 4, Pages (October 2010) DOI: /j.athoracsur Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 High molecular weight von Willebrand factor multimer grading: the gel reflects increasing severity of multimer loss from left to right. Grade 0 indicates normal levels with no multimer loss, grade 2 indicates moderate multimer loss, and grade 3 indicates severe multimer loss. (LVAD = left ventricular assist device.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 High molecular weight von Willebrand factor multimer grade loss surrounding continuous-flow left ventricular assist device (LVAD) implantation is shown. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 von Willebrand factor antigen (vWF:Ag): (A) Responses from individual patients; bleeders are indicated by black lines, nonbleeders by gray lines. (B) Mean ± SE for bleeders (black) and nonbleeders (gray). (VAD = ventricular assist device.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Factor VIII: (A) Responses from individual patients; bleeders are indicated by black lines, nonbleeders by gray lines. (B) Mean ± SE for bleeders (black) and nonbleeders (gray). (VAD = ventricular assist device.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions


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