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Cortex Shatters the Glass Ceiling

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1 Cortex Shatters the Glass Ceiling
Edmund Au, Gord Fishell  Cell Stem Cell  Volume 3, Issue 5, Pages (November 2008) DOI: /j.stem Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 ESC-Derived Telencephalic Precursors Self-Organize into Rosette Structures Reminiscent of Early Cortical Development (A) Early embryoid bodies are hollow spheres with proliferative cells (pink) lining the lumen. Over time, the sphere collapses into numerous rosettes. Pax6+ VZ cells are deep, surrounded by Tbr2+/Pax6+ SVZ-like cells and a superficial layer of Tbr1+/Tuj1 neurons. Reelin+/calretinin+ Cajal-Retzius cells are found at the outer edge of the rosettes. (B) Coronal plane of E11.5 mouse brain. The layers of the cortex form with a VZ found deep, preplate (PP) and SVZ in the middle and a marginal zone (MZ) found superficially. Cell Stem Cell 2008 3, DOI: ( /j.stem ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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