1. Ion Channels and Synaptic Organization
J.Troy Littleton, Barry Ganetzky 
Neuron 
Volume 26, Issue 1, Pages (April 2000)
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2. Figure 1 The Voltage-Dependent Calcium Channel Family
A nearest neighbor dendrogram for the voltage-gated calcium channel superfamily is shown. Four calcium channel subfamilies are evolutionarily conserved from invertebrates to mammals. Abbreviations: H, human; R, rat; Ce, C. elegans; Dm, Drosophila melanogaster.
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3. Figure 2 The Superfamily of Excitatory Glutamate Receptors
A dendrogram of the identified glutamate receptors from the Drosophila and C. elegans genomes, as well as known human subtypes, is shown. The C. elegans gene products are identified by their CE designation, while the Drosophila gene products are listed by their Celera transcript number (CT). Although many of the invertebrate glutamate receptors do not unambiguously fall into AMPA, kainate, or δ subfamilies, many of the outliers show strong homology to one of the three channel subtypes as described in the text. Abbreviations: H, human; R, rat; Ce, C. elegans; Dm, Drosophila melanogaster. Our analysis of genomic data included BLASTP searches of proteins encoded by genes predicted by Genescan, Genie2, and sequence homology to known proteins, as well as TBLASTN searches of the Celera 12X Drosophila genome coverage with known ion channel or synaptic proteins. 99.7% of known Drosophila genes are covered by the Celera contigs, suggesting out searches have covered almost all of the coding potential of the Drosophila genome. The CT sequence described in the figures can be accessed through the Berkeley Drosophila Genome Project web site (
Neuron  , 35-43DOI: ( /S (00) )

4. Figure 3
The Nicotinic Acetylcholine Receptor Family in Drosophila and Humans
Nearest neighbor dendrogram of the known human nACh receptors and the known (Dm) and predicted (CT#) Drosophila family members.
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5. Figure 4 Diversity and Structure of the TRP Superfamily
(A) Nearest neighbor dendrogram of the TRP family reveals four distinct subfamilies.
(B) Predicted domain structure of the C. elegans OSM9 channel. This prototypical member of the TRP family shows the conserved N-terminal ankryin repeats (absent in the polycystin-2 subfamily) and the TRP six transmembrane cation channel.
(C) Representative domain structure of members of the TRP superfamily.
Abbreviations: H, human; R, rat; Ce, C. elegans; Dm, Drosophila melanogaster; CT, Celera transcript.
Neuron  , 35-43DOI: ( /S (00) )