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Sweet Talk: Regulating Glucose Metabolism in Toxoplasma

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Presentation on theme: "Sweet Talk: Regulating Glucose Metabolism in Toxoplasma"— Presentation transcript:

1 Sweet Talk: Regulating Glucose Metabolism in Toxoplasma
Ann M. Guggisberg, Audrey R. Odom  Cell Host & Microbe  Volume 18, Issue 2, Pages (August 2015) DOI: /j.chom Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic of Metabolic Regulation by TgFBP2
TgFBP2 participates in gluconeogenesis (glucose synthesis), the reverse of glycolysis (glucose breakdown). TgFBP2 is co-expressed alongside glycolytic enzymes, such as phosphofructokinase (PFK), and is required for growth, even in glucose-rich conditions. This points to a novel role for TgFBP2 as a metabolic regulator, allowing the cell to “fine-tune” its metabolism and direct metabolic flux. Metabolic consequences of TgFBP2 knockdown include increased lactate production and a decrease in TCA cycle intermediates. Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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