1. Technical Solutions The Final Results
Securing high efficiency genes engaged to the isoprenoids precursors pathway
The small quantity of Isoprenoids products in nature from lack of limited precursors.
The insufficiency of genomic network information about diverse biosynthesis pathways for producing multiform precursors.
The reduced productivity due to growth inhibition by over-producing of various precursors.
Technical Solutions
The Final Results
Construction of heterologous MVA pathway modules systems in E.coli
Genome integration of optimized MVA pathway modules in E.coli
Analysis and control of Isoprenoids biosynthsis pathway network in recombinant E.coli
Isopentenyl pyrophosphate (IPP)
The problems of Isoprenoids and other materials production in microbial organism
Development of the module system for producing high efficiency Isoprenoids precursors.
Identification of Isoprenoids biosynthsis pathway network in E.coli by introducing heterologous mevalonate pathway
Optimization of Isoprenoids producing biosynthtic pathway in E.coli through control of genome expression levels and network analysis
Optimization of MVA downstream pathway modules by synthetic promoter and RBS engineering
Construction of Isoprenoids precursors producing conditions for the scale-up systems.
Application of hetelogous MVA pathway in the carotenoids and ginsenoside biosynthsis patthways
Optimization of MVA upstream pathway modules by synthetic promoter and ribosome binding site(RBS) engineering