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Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations  Dennis G. Moledina, MBBS, Selin Isguven,

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Presentation on theme: "Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations  Dennis G. Moledina, MBBS, Selin Isguven,"— Presentation transcript:

1 Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations  Dennis G. Moledina, MBBS, Selin Isguven, BS, Eric McArthur, MS, Heather Thiessen-Philbrook, MMath, Amit X. Garg, MD, PhD, Michael Shlipak, MD, Richard Whitlock, MD, Peter A. Kavsak, PhD, Steven G. Coca, MD, MS, Chirag R. Parikh, MD, PhD  The Annals of Thoracic Surgery  Volume 104, Issue 2, Pages (August 2017) DOI: /j.athoracsur Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 (A) Monocyte chemotactic protein-1 (MCP-1) levels are significantly higher in patients with acute kidney injury (AKI). *p < at all time-points. (B) MCP-1 levels are significantly higher in those who died. *p = on the preoperative time point, p = 0.02 on the first postoperative day, and p < at all other time points. The top and bottom of the box represent the interquartile range, and the horizontal line represents the median. Day 1 refers to 0 to 6 hours after the operation, day 2 corresponds to 48 hours after the operation, and day 3 corresponds to 72 hours after the operation. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 (A) Probability of death after a cardiac operation by preoperative monocyte chemotactic protein-1 (MCP-1) tertiles (T). (B) Probability of death after a cardiac operation by postoperative MCP-1 tertiles. MCP-1 tertile cutoffs (pg/mL): Preoperative: T1, 12 to 147; T2, 147 to 196; T3, 196 to 1,581. Postoperative: T1, 40 to 359; T2, 359 to 600; T3, 600 to 1,581. Median length of follow-up was 2.9 years (interquartile range, 2.2 to 3.5 years). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions


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