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BMP Signaling Goes Posttranscriptional in a microRNA Sort of Way

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Presentation on theme: "BMP Signaling Goes Posttranscriptional in a microRNA Sort of Way"— Presentation transcript:

1 BMP Signaling Goes Posttranscriptional in a microRNA Sort of Way
Catherine A. Reinke, Richard W. Carthew  Developmental Cell  Volume 15, Issue 2, Pages (August 2008) DOI: /j.devcel Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 A Model for the Regulation of miRNA Maturation in Response to TGF-β Superfamily Signaling BMP and TGF-β signaling stimulates the production of pre-miR-21, affecting downstream miR-21 targets such as PDCD4. Activated R-SMAD interaction with the pri-miRNA processing machinery is postulated to mediate posttranscriptional regulation of miRNAs. BMPs are proposed to affect the interaction between R-SMAD and pri-miRNAs primarily by controlling SMAD nuclear localization, as a nonphosphorylatable R-SMAD mutant retains the ability to interact with miR-21 in vitro. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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