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Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms  Brajesh K. Lal,

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Presentation on theme: "Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms  Brajesh K. Lal,"— Presentation transcript:

1 Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms  Brajesh K. Lal, MD, Wei Zhou, MD, Ziyi Li, MPH, Tassos Kyriakides, PhD, Jon Matsumura, MD, Frank A. Lederle, MD, Julie Freischlag, MD  Journal of Vascular Surgery  Volume 62, Issue 6, Pages (December 2015) DOI: /j.jvs Copyright © Terms and Conditions

2 Fig 1 Endoleak characteristics. A, Distribution of types of endoleaks identified in 135 individuals undergoing endovascular aneurysm repair (EVAR) in the Open Versus Endovascular Repair (OVER) of Abdominal Aortic Aneurysms trial. B, Number of endoleaks identified in 135 patients at different intervals during the follow-up after the EVAR procedure. Note that several patients had more than one endoleak. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

3 Fig 2 Aneurysm diameter changes by device type. Results are censored by the first secondary intervention. Ancure, Guidant, Menlo Park, Calif (dotted black line); AneuRx, Medtronic, Minneapolis, Minn (red line); Endologix, Irvine, Calif (dotted blue line); Excluder, W. L. Gore and Associates, Flagstaff, Ariz (dashed purple line); Zenith, Cook, Bloomington, Ind (dashed green line). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

4 Fig 3 Aneurysm diameter changes by endoleak. A, Change in the largest aortic aneurysm diameter over time in patients with (blue line) vs those without (black line) an endoleak (P = .0001). B, Change in the largest aortic aneurysm diameter over time in patients with type II (red line) vs types I, III, IV, and indeterminate (black line) endoleaks (P = .93). C, Change in the largest aortic aneurysm diameter over time in patients with early (≤1 year postprocedure; black line) vs delayed (blue line) endoleaks (P < .0001). Results shown in A, B, and C were censored by first secondary intervention. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

5 Fig 3 Aneurysm diameter changes by endoleak. A, Change in the largest aortic aneurysm diameter over time in patients with (blue line) vs those without (black line) an endoleak (P = .0001). B, Change in the largest aortic aneurysm diameter over time in patients with type II (red line) vs types I, III, IV, and indeterminate (black line) endoleaks (P = .93). C, Change in the largest aortic aneurysm diameter over time in patients with early (≤1 year postprocedure; black line) vs delayed (blue line) endoleaks (P < .0001). Results shown in A, B, and C were censored by first secondary intervention. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

6 Fig 4 Time from endoleak detection to resolution after a secondary intervention for type II endoleaks (black line) vs types I, III, IV, and indeterminate endoleaks (red line). The respectively colored dashed lines indicate the upper and lower confidence intervals (CIs). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

7 Fig 5 Mortality and rupture with endoleaks. Time from randomization to death/end of study in patients with an endoleak (black line) vs those without an endoleak (red line). Excludes patients who underwent secondary interventions for endoleaks. The respectively colored dashed lines indicate the upper and lower confidence intervals (CIs). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

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