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Zuhair K. Ballas, MD  Journal of Allergy and Clinical Immunology 

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Presentation on theme: "Zuhair K. Ballas, MD  Journal of Allergy and Clinical Immunology "— Presentation transcript:

1 The 2018 American Academy of Allergy, Asthma & Immunology Foundation Faculty Development awardees 
Zuhair K. Ballas, MD  Journal of Allergy and Clinical Immunology  Volume 142, Issue 1, Pages (July 2018) DOI: /j.jaci Copyright © Terms and Conditions

2 Fig 1 Sarah E. Henrickson, MD, PhD (left); Lori Broderick, MD, PhD (center); and Adora E. Lin, MD, PhD (right). Journal of Allergy and Clinical Immunology  , 67-70DOI: ( /j.jaci ) Copyright © Terms and Conditions

3 Fig 2 Research by Dr Henrickson. In certain PID, there is an imbalance in baseline T cell signaling between CD28 (stimulatory) and CTLA-4 (inhibitory) signals and this leads to chronic increased signaling: A) homeostasis; B) less negative signal; C) more positive signal. CTLA-4, Cytotoxic T lymphocyte–associated antigen 4; mTOR, mechanistic target of rapamycin; PI3K, phosphoinositide 3-kinase; TCR, T-cell receptor. Journal of Allergy and Clinical Immunology  , 67-70DOI: ( /j.jaci ) Copyright © Terms and Conditions

4 Fig 3 Graphical abstract: Research by Dr Broderick.
Journal of Allergy and Clinical Immunology  , 67-70DOI: ( /j.jaci ) Copyright © Terms and Conditions

5 Fig 4 Graphical abstract: Research by Dr Lin.
Journal of Allergy and Clinical Immunology  , 67-70DOI: ( /j.jaci ) Copyright © Terms and Conditions


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