1. IgE sensitization in relation to preschool eczema and filaggrin mutation 
Emma Kristin Johansson, MD, Anna Bergström, PhD, Inger Kull, RN, PhD, Tomas Lind, Cilla Söderhäll, PhD, Marianne van Hage, MD, PhD, Magnus Wickman, MD, PhD, Natalia Ballardini, MD, PhD, Carl-Fredrik Wahlgren, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 140, Issue 6, Pages e5 (December 2017)
DOI: /j.jaci
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Flow chart of the study showing children included in different analyses of IgE sensitization in relation to PSE and FLG mutation. PSE was defined as eczema between 0 and 4 years of age based on questionnaire data.
Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci )
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
A, Association between PSE and IgE sensitization at 4, 8, and 16 years of age. Children with data on PSE who provided blood at least once were included in the analysis (n = 3201). We used a logistic regression model with GEE adjusted for sex and heredity. Effect modification was tested for sex, heredity, breast-feeding, parental smoking during infancy, mother's age, socioeconomic status, and FLG mutation. B, Association between FLG mutation and IgE sensitization at 4, 8, and 16 years of age. Children from the BAMSE cohort with data on FLG mutation and PSE were included in the analysis (n = 1890). We used a logistic regression model with GEE adjusted for PSE, sex, and heredity. Effect modification was tested for sex, heredity, breast-feeding, parental smoking during infancy, mother's age, socioeconomic status, and PSE.
Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci )
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Fig 3
Proportions of children with monosensitization, oligosensitization, and polysensitization among IgE-sensitized children with and without PSE at 4, 8, and 16 years of age in the BAMSE cohort.
Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci )
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5. Fig 4
Pattern of IgE sensitization at 4 (A), 8 (B), and 16 (C) years of age by PSE. Bars represent the proportions of children in each group with specific IgE ≥0.35 kUA/L for the respective allergen. Children in the BAMSE cohort with any IgE sensitization and complete data on specific IgE measurement at respective ages were included. *Significant differences.
Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci )
Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions