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Combinatorial Haplo-Deficient Tumor Suppression in 7q-Deficient Myelodysplastic Syndrome and Acute Myeloid Leukemia  Britta Will, Ulrich Steidl  Cancer.

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Presentation on theme: "Combinatorial Haplo-Deficient Tumor Suppression in 7q-Deficient Myelodysplastic Syndrome and Acute Myeloid Leukemia  Britta Will, Ulrich Steidl  Cancer."— Presentation transcript:

1 Combinatorial Haplo-Deficient Tumor Suppression in 7q-Deficient Myelodysplastic Syndrome and Acute Myeloid Leukemia  Britta Will, Ulrich Steidl  Cancer Cell  Volume 25, Issue 5, Pages (May 2014) DOI: /j.ccr Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Leukemogenic Cooperation of Mll3 and Nf1 Haploinsufficiency in a p53-Deficient Background Adoptive transfer of lentivirally transduced hematopoietic stem and progenitor cells (HSPCs) into syngeneic recipient animals leads to an AML recapitulating hallmarks of human −7/7q- AML, in contrast to thymic lymphoma induced by p53 deficiency only. Cancer Cell  , DOI: ( /j.ccr ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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