1. Plasma Glucose Homeostasis Widmaier et al., p. 567-580
Glucose metabolism
Hormonal Control
Disruptions of glucose homeostasis
Case Study

2. Homeostasis of Plasma Glucose Concentration
Normal physiological range: mg/dl
What is the set point?
Why is too much plasma glucose harmful?
Plasma glucose concentration = glucose entering the plasma – glucose leaving the plasma
What are the mechanisms that regulate plasma glucose concentration?
What are the components of the negative feedback loop:
Glucose receptors?
Afferent pathway?
Integrator?
Efferent pathway(s)?
Effector organ(s)?
Phases: *absorptive, *post-absorptive, and fasting

3. Absorptive Phase Fig. 16.01 =sink Hepatic Portal System
Lipoprotein Lipase
Absorptive Phase
16.01.jpg
Hepatic Portal System
Once inside, glucose is converted to something else, thereby maintaining a concentration gradient for facilitated diffusion of glucose into cells.