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Apoptotic regulatory proteins in renal injury

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Presentation on theme: "Apoptotic regulatory proteins in renal injury"— Presentation transcript:

1 Apoptotic regulatory proteins in renal injury
Alberto Ortiz  Kidney International  Volume 58, Issue 1, Pages (July 2000) DOI: /j x Copyright © 2000 International Society of Nephrology Terms and Conditions

2 Figure 1 Apoptotic cells within tubular wall (arrows) (H&E stain, original magnification ×200). Courtesy of Antonio Barat, M.D., Fundación Jiménez Díaz, Madrid, Spain. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

3 Figure 2 Pyknotic nuclei are small condensed nuclei from apoptotic cells. Note pyknotic nuclei and shrunken cytoplasm in murine tubular epithelial cells exposed to 300 μg/mL acetaminophen for 24 hours (arrow) (H&E stain, original magnification ×400). Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

4 Figure 3 Extracellular regulation of lethal cytokine-induced cell death: the case of Fas ligand (FasL). Abbreviations are: DcR3, decoy receptor-3; sFas, soluble Fas; sFasL, soluble FasL. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

5 Figure 4 Intracellular pathways for cell death can be activated by death receptors or cell stress and are antagonized by molecules such as Bcl-2/BclxL, FLIP, IAP, and extracellular survival factors. Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

6 Figure 5 Schema of the relative timing and extent of apoptosis in relation to mitosis determines ultimate cell number. (A) Resolution of injury. (B) Atrophy. Symbols are: dotted line, apoptosis; dashed line, mitosis; solid line, live cells. An excess apoptosis limited in time can restore normal cell number (A), but persistent apoptosis can result in tissue atrophy (B). Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions

7 Kidney International 2000 58, 467-485DOI: (10. 1046/j. 1523-1755. 2000
Kidney International  , DOI: ( /j x) Copyright © 2000 International Society of Nephrology Terms and Conditions


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