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hsp90: Twist and Fold Cell

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1 hsp90: Twist and Fold Cell
Klaus Richter, Johannes Buchner  Cell  Volume 127, Issue 2, Pages (October 2006) DOI: /j.cell Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 The ATPase Cycle of HtpG and Hsp90
Based on the recent structures of apo-HtpG, HtpG-ADP, and yeast hsp90-AMP-PNP, a cycle of conformational changes can be reconstituted. The slow steps during the ATPase cycle are the conformational changes preceeding ATP hydrolysis. These steps are regulated by Sti1, Cdc37 (inhibition), and Aha1 (stimulation). In contrast, the cochaperone p23 binds to the ATP-complexed and catalytically active conformation and slows down ATP turnover. Cell  , DOI: ( /j.cell ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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