1. Volume 116, Issue 1, Pages 38-45 (January 1999)
The κ agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome 
Michel Delvaux, Dominique Louvel, Emmanuel Lagier, Bruno Scherrer, Jean-Louis Abitbol, Jacques Frexinos 
Gastroenterology 
Volume 116, Issue 1, Pages (January 1999)
DOI: /S (99)70226-X
Copyright © 1999 American Gastroenterological Association Terms and Conditions

2. Fig. 1
Study design, including the phase of selection of patients and the experimental procedures in protocols 1 (distention) and 2 (tone recording).
Gastroenterology  , 38-45DOI: ( /S (99)70226-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

3. Fig. 2
Cumulative number of patients positively responding for the (A) first sensation threshold and (B) pain threshold on placebo ( ) and 100 mg fedotozine (—) intravenously.
Gastroenterology  , 38-45DOI: ( /S (99)70226-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

4. Fig. 2
Cumulative number of patients positively responding for the (A) first sensation threshold and (B) pain threshold on placebo ( ) and 100 mg fedotozine (—) intravenously.
Gastroenterology  , 38-45DOI: ( /S (99)70226-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

5. Fig. 3
Volume measured in the barostat bag at the (A) first sensation and (B) pain thresholds. Baseline distention was performed in the morning without any treatment. A second distention session was performed in the afternoon during the random infusion of placebo or 100 mg fedotozine.
Gastroenterology  , 38-45DOI: ( /S (99)70226-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

6. Fig. 3
Volume measured in the barostat bag at the (A) first sensation and (B) pain thresholds. Baseline distention was performed in the morning without any treatment. A second distention session was performed in the afternoon during the random infusion of placebo or 100 mg fedotozine.
Gastroenterology  , 38-45DOI: ( /S (99)70226-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

7. Fig. 4
Pressure-volume curve on placebo (▩) and 100 mg fedotozine (■) intravenously. Values are expressed as means ± SD of volumes measured in each patient.
Gastroenterology  , 38-45DOI: ( /S (99)70226-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

8. Fig. 5
Volume of the barostat bag placed in the left colon under a constant operating pressure, defined as the pressure allowing the recording of respiratory movements plus 2 mm Hg. In the fasted state, the bag volume is slightly increased on fedotozine compared with placebo (P = 0.035), indicating that fedotozine might induce a moderate relaxation of the colon. Variations of the barostat bag volume reflect changes in colonic tone. These changes are characterized by a dramatic decrease of the bag volume in the postprandial period on both placebo (■) and fedotozine (▩).
Gastroenterology  , 38-45DOI: ( /S (99)70226-X)
Copyright © 1999 American Gastroenterological Association Terms and Conditions