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Rémy Denzler, Markus Stoffel  Molecular Cell 

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Presentation on theme: "Rémy Denzler, Markus Stoffel  Molecular Cell "— Presentation transcript:

1 The Long, the Short, and the Unstructured: A Unifying Model of miRNA Biogenesis 
Rémy Denzler, Markus Stoffel  Molecular Cell  Volume 60, Issue 1, Pages 4-6 (October 2015) DOI: /j.molcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 pri-miRNA Structure Influences Its Processing Efficiency
(A) Schematic illustration of pri-miRNA biogenesis depicting the sequence determinants in mammalian pri-miRNA, and its orientation in relation to components of the Microprocessor complex. (B) Summary of how the sequence and structure determinants of mammalian pri-miRNA influence processing efficiency in pri-miRNA that have different stem-loop lengths and contain unstructured features (mismatches and bulges in the stem). Molecular Cell  , 4-6DOI: ( /j.molcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

3 Figure 2 Impact of pri-miRNA Features for Technical Applications and Biological Insights Molecular Cell  , 4-6DOI: ( /j.molcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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