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A randomized, controlled comparison of ibuprofen at the maximal over-the-counter dose compared with prescription-dose celecoxib on upper gastrointestinal.

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Presentation on theme: "A randomized, controlled comparison of ibuprofen at the maximal over-the-counter dose compared with prescription-dose celecoxib on upper gastrointestinal."— Presentation transcript:

1 A randomized, controlled comparison of ibuprofen at the maximal over-the-counter dose compared with prescription-dose celecoxib on upper gastrointestinal mucosal injury  James M. Scheiman, Byron Cryer, Michael B. Kimmey, Richard I. Rothstein, Dennis S. Riff, Michael M. Wolfe  Clinical Gastroenterology and Hepatology  Volume 2, Issue 4, Pages (April 2004) DOI: /S (04)

2 Figure 1 Incidence of endoscopic ulcers in patients administered placebo; naproxen, 1000 mg/d; ibuprofen, 1200 mg/d; and celecoxib, 200 mg/d. Values shown as mean + SE. ∗P < 0.01 vs. placebo. #P = vs. celecoxib. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04) )

3 Figure 2 Incidence of erosions in patients administered placebo; naproxen, 1000 mg/d; ibuprofen, 1200 mg/d; and celecoxib, 200 mg/d. Values shown as mean + SE. ∗P < 0.01 vs. placebo. #P = vs. celecoxib. Clinical Gastroenterology and Hepatology 2004 2, DOI: ( /S (04) )


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