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Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration

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Presentation on theme: "Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration"— Presentation transcript:

1 Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration
Shana Elbaum-Garfinkle, Clifford P. Brangwynne  Developmental Cell  Volume 35, Issue 5, Pages (December 2015) DOI: /j.devcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Model of FUS Protein Assemblies
FUS wild-type protein can assemble into liquid or hydrogel states that can be fully reversed to a mixed bulk solution. FUS ALS/FTD mutations lead to assembly of liquids and/or gels that can no longer be reversed, resulting in the retention of additional proteins. This insoluble, irreversible protein phase correlates with deteriorated motor nerve function and decreased lifespan, characteristic of ALS/FTD diseases. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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