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Relationship between Genotype and Phenotype

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Presentation on theme: "Relationship between Genotype and Phenotype"— Presentation transcript:

1 Relationship between Genotype and Phenotype
Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation amino acid sequence protein function phenotype organism

2 Gene Sites Sensitive to Mutation
null if splice junction is affected no effect if mutation is in the middle of the intron or not the branch point Refer to Figure 2-13, Griffiths et al., 2015.

3 Relationship between Genotype and Phenotype
Molecular Basis for Relationship between Genotype and Phenotype genotype DNA DNA sequence transcription RNA translation amino acid sequence protein function phenotype organism

4 Complementation Analysis
Allelic Non-Allelic m m2 m m2 Cis Trans Wild-type Wild-type m2 m2 m m Mutant Wild-type Mutant alleles complement if wild-type phenotype results when two haploid genomes carrying different mutations are united in the same cell.

5 How many loci are represented here?
Mutant I X Mutant II F1 a b c d e f o + + o o + a + o + + + + b + + o + + o c o + + o o + d o + + o o + e + + o + + o f


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