1. Epithelial and Mesenchymal Contribution to the Niche: A Safeguard for Intestinal Stem Cell Homeostasis 
Nicholas R. Smith, Paige S. Davies, Alain D. Silk, Melissa H. Wong 
Gastroenterology 
Volume 143, Issue 6, Pages (December 2012)
DOI: /j.gastro
Copyright © 2012 AGA Institute Terms and Conditions

2. Figure 1
Comparison of in vivo (left) and in vitro (right) signaling support to the ISC. Signaling networks between the PC and stem cell seem to be broadly conserved. However, disruption of one element of a single pathway highlights the important compensation wired into the system where in vivo environments can rely on mesenchymal cells to maintain signaling homeostasis. Wnt, Notch, and EGF signaling pathways are key players in the balance between stem cell maintenance and differentiation.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2012 AGA Institute Terms and Conditions