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Essential Role for Oxidative Phosphorylation in Cancer Progression

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Presentation on theme: "Essential Role for Oxidative Phosphorylation in Cancer Progression"— Presentation transcript:

1 Essential Role for Oxidative Phosphorylation in Cancer Progression
Maria Chiara Maiuri, Guido Kroemer  Cell Metabolism  Volume 21, Issue 1, Pages (January 2015) DOI: /j.cmet Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Cancer Progression of Initially mtDNA-Deficient Cells
(A) Consequences of mtDNA recovery on the properties of tumors generated from originally mtDNA-deficient (ρ° cells). (B–D) Potential mechanisms of host mtDNA uptake by ρ° cells. ρ° cells might incorporate “naked” DNA from the host (B), phagocytose portions of host cells that comprise mtDNA-containing mitochondria (C), or fuse with host cells (D). In this latter scenario, the originally ρ° cell would not recover only mtDNA, but would also recover chromosomes from the nuclear host genome. Cell Metabolism  , 11-12DOI: ( /j.cmet ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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