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Oxytocin Mobilizes Midbrain Dopamine toward Sociality

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Presentation on theme: "Oxytocin Mobilizes Midbrain Dopamine toward Sociality"— Presentation transcript:

1 Oxytocin Mobilizes Midbrain Dopamine toward Sociality
Alexandre Charlet, Valery Grinevich  Neuron  Volume 95, Issue 2, Pages (July 2017) DOI: /j.neuron Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Oxytocin-Midbrain Dopamine Circuit for Modulation of Social Behavior The schema depicts the authors’ finding on distinct projections of parvocellular OT neurons to the ventral tegmental area (VTA) and substantia nigra (SN). The axonal OT release in these regions led to opposite effects: the activation of VTA DA neurons and the inhibition—via interneurons—of SN DA neurons. The forebrain projections of these neurons to prefrontal cortex (PFC), caudate putamen (CPU), nucleus accumbens (Acb), and ventral hippocampus (vHippo) could enhance the salience of partner-directed behavior versus exploratory behavior. The proposed behavioral hypothesis should be demonstrated with actual experiments. Neuron  , DOI: ( /j.neuron ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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