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In vivo assessment of endothelial function in human lower extremity arteries  Vikram S. Kashyap, MD, Ryan O. Lakin, MD, Lindsay E. Feiten, BS, Paul D.

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Presentation on theme: "In vivo assessment of endothelial function in human lower extremity arteries  Vikram S. Kashyap, MD, Ryan O. Lakin, MD, Lindsay E. Feiten, BS, Paul D."— Presentation transcript:

1 In vivo assessment of endothelial function in human lower extremity arteries 
Vikram S. Kashyap, MD, Ryan O. Lakin, MD, Lindsay E. Feiten, BS, Paul D. Bishop, MSEE, Timur P. Sarac, MD  Journal of Vascular Surgery  Volume 58, Issue 5, Pages (November 2013) DOI: /j.jvs Copyright © 2013 Society for Vascular Surgery Terms and Conditions

2 Fig 1 In this lower extremity angiogram performed with an intravascular ultrasound (IVUS) catheter and a inch Doppler flow wire, the IVUS probe is approximately at marker 200 (arrow) and the wire sensor is beyond marker 240. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

3 Fig 2 A, B-mode intravascular ultrasound (IVUS) image of an artery depicts the three layers of the arterial wall. B, Border analysis documents luminal (light blue) and medial-adventitial (dark blue) borders, C, Virtual histology is performed using a modified coronary artery algorithm classified by color, indicating calcium (white), necrosis (red), and fibrous (green) plaque components. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Average peak velocity (APV) showed statistically significant increases of 26%, 46%, and 63% in response to incremental doses of acetylcholine (Ach). The error bars show the standard error of the mean. P = by analysis of variance. EDR, Endothelial-dependent vasorelaxation. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Percentage change in limb volumetric flow showed statistically significant increases in response to incremental doses of acetylcholine (Ach). The error bars show the standard error of the mean. P = by analysis of variance. EDR, Endothelial-dependent vasorelaxation. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Lower extremity levels of nitric oxide metabolites (NOx) were slightly lower than systemic venous levels. P = The error bars show the standard error of the mean. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

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