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Inosine Triphosphate Pyrophosphatase and Thiopurine S-Methyltransferase Genotypes Relationship to Azathioprine-Induced Myelosuppression  Zuzana Zelinkova,

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Presentation on theme: "Inosine Triphosphate Pyrophosphatase and Thiopurine S-Methyltransferase Genotypes Relationship to Azathioprine-Induced Myelosuppression  Zuzana Zelinkova,"— Presentation transcript:

1 Inosine Triphosphate Pyrophosphatase and Thiopurine S-Methyltransferase Genotypes Relationship to Azathioprine-Induced Myelosuppression  Zuzana Zelinkova, Luc J.J. Derijks, Pieter C.F. Stokkers, Esther W.M. Vogels, Antoine H.C. van Kampen, Wouter L. Curvers, Danny Cohn, Sander J.H. van Deventer, Daniël W. Hommes  Clinical Gastroenterology and Hepatology  Volume 4, Issue 1, Pages (January 2006) DOI: /j.cgh Copyright © 2006 American Gastroenterological Association Terms and Conditions

2 Figure 1 Proposed thiopurine metabolism.
Clinical Gastroenterology and Hepatology 2006 4, 44-49DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

3 Figure 2 TPMT genotypes. Clinical Gastroenterology and Hepatology 2006 4, 44-49DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

4 Figure 3 Location of the 5 single-nucleotide polymorphisms on the ITPA gene. Clinical Gastroenterology and Hepatology 2006 4, 44-49DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions

5 Figure 4 Percentages of ITPA and TPMT (*3A or *3C) mutant allele carriers among AZA users with respect to the development of leukopenia. *P = .046; OR = 3.504; 95% CI, 1.119–10.971; **P = .004; OR = 6.316; 95% CI, 2.141– ■, Wild type; □, mutant allele carriers. Clinical Gastroenterology and Hepatology 2006 4, 44-49DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions


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