1. Brain Fraction and SPM Normalized Penumbra
MSmcDESPOT
Brain Fraction and SPM Normalized Penumbra

2. Updated EDSS

3. Updated EDSS

4. Updated EDSS

5. Updated EDSS
This is with DAWM defined by SPM penumbra in WM containing lesion cores. Overall SPM significantly shrunk the DAWM selection by about order of 10 in vol.

6. Brain Fraction with Prelim. GM
Similar to what was seen in Nov.

7. MWF Std. Dev. In Normals 0–0.11 scale
Clearly there is high variation in the GM, most likely due to registration imperfections
Similarly at edges of ventricles

8. FLAIR Std. Dev. In Normals – Raw
Scale 0–50, not too relevant here since not quantitative
Inhomogeneity variation across normals caused a higher degree of fluctuation in the forebrain

9. FLAIR Std. Dev. In Normals – Max Normalized
Not sure how to window properly so that the std. dev. maps are comparable
Wanted to see the image get darker -> lower std. dev. -> tighter distribution
Again the forebrain has higher variability

10. FLAIR Std. Dev. In Normals – SPM Normalized
0–50, same scale as Raw
Removes forebrain variability artifact
However, the image did not darken vs. Raw so the distribution did not get tighter

11. FLAIR Std. Dev. In Normals – SPM Normalized
This is auto-windowed to the “robust range” as the max normalized one was also
Only very slight brightening vs range
Interpretation:
Max normalized seems to achieve a lower standard deviation across normals, this is confirmed by the larger DAWM selection