1. EPIC: Balloon Angioplasty
Primary Endpoint: Death, MI, UTVR at 30 days
Placebo + heparin (ACT  300 sec) (n=696)
Abciximab 0.25mg/kg bolus + heparin (ACT  300 sec) (n=395)
Abciximab 0.25mg/kg bolus / 10 µg/kg infusion + heparin (ACT  300 sec) (n=708)
4.5%  (P<0.004)
1.4%  (P=ns)
% events
12.8%
11.4%
8.3%
The EPIC investigators. N. Engl J Med. 1994; 330:

2. EPIC Results 30 Day Death/MI 3.5%  (P=0.015)
6 Month Death/MI 3.9%  (P=0.019)
30 Day TVR 3.8%  (P=0.003)
6 Month TVR 5.8%  (P=0.007)
9.6%
6.1%
12.8%
8.9%
7.8%
4.0%
22.3%
16.5%
1.4%
6.6%
Major TIMI Bleeding
Placebo + heparin (ACT  300 sec) (n=696)
Abciximab + heparin (ACT  300 sec) (n=708)
% events
The EPIC investigators. N. Engl J Med. 1994; 330: