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GroEL: More than Just a Folding Cage

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Presentation on theme: "GroEL: More than Just a Folding Cage"— Presentation transcript:

1 GroEL: More than Just a Folding Cage
Sheena E. Radford  Cell  Volume 125, Issue 5, Pages (June 2006) DOI: /j.cell Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Altering the Size or Charge of the GroEL Folding Cavity Can Have a Profound Influence on Protein Folding (Left) Wild-type GroEL/GroES with a folding substrate (green) is shown. (Middle) Changing the cavity size by deleting or replicating the motifs at the C terminus of each GroEL subunit affects substrate folding. (Right) Alteration of the surface charge of the cavity in a version of GroEL (named SR1) that contains only a single ring can also affect the folding of some substrates. Cell  , DOI: ( /j.cell ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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