1. MMV: Origins, Mission & Vision
Swiss not-for-profit foundation operating as a public-private partnership
Founded in 1999 by WHO/TDR, IFPMA, World Bank, Donor governments and philanthropic foundations
Mission
Discover, develop and deliver safe, effective and affordable antimalarials to treat and protect people most at risk of malaria
Provide the public health community with the most appropriate tools to achieve maximum public health impact
Vision
A world in which innovative medicines will cure and protect the millions at risk of malaria and help to ultimately eradicate this terrible disease

2. First Generation of Synthetic Peroxides
OZ277 or RBx11160 O N H 2

3. Objectives: Synthetic Peroxides (OZ) Project
First Generation OZ project aimed to:
identify a new class of peroxides
more potent than the currently available semi-synthetic artemisinin derivatives in reducing parasite burden
fully synthetic
low cost (< $1 USD per treatment when used in combination)
3 day treatment regimen when used in combination
Next Generation OZ project extends these goals to also include:
provision in combination of a single-dose oral cure for patients with uncomplicated P. falciparum malaria (and possibly P. vivax)
potential for prophylactic treatment and intermittent preventative treatment in pregnant women and infants (IPTp and IPTi)

4. OZ439 second generation ozonide: on the path to a single dose cure
OZ439 clearly better than current therapies in a single dose
mouse model (100 mg/kg) AS
Control
OZ277 CQ
Mef
OZ A
OZ B
OZ C
OZ401
OZ439
OZ493