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Percentage of patients achieving DAS28 (CRP) < 3

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Presentation on theme: "Percentage of patients achieving DAS28 (CRP) < 3"— Presentation transcript:

1 Percentage of patients achieving DAS28 (CRP) < 3
Percentage of patients achieving DAS28 (CRP) < 3.2 (A), DAS28 (CRP) < 2.6 (B), CDC (C), and CDR (D) during the course of 10 years of ADA ± MTX treatment. Percentage of patients achieving DAS28 (CRP) < 3.2 (A), DAS28 (CRP) < 2.6 (B), CDC (C), and CDR (D) during the course of 10 years of ADA ± MTX treatment. Lines with symbols represent observed response rate based on all randomized patients (n = 268, 274, and 257 for adalimumab + MTX, adalimumab, and MTX, respectively). Dashed lines represent response rate using nonresponder imputation based on all patients entering open-label extension (n = 183, 159, and 155 for adalimumab + MTX, adalimumab, and MTX, respectively). Bar graphs reflect data as observed at final visit using last observation carried forward method for all randomized patients (n = 268, 274, and 257 for adalimumab + MTX, adalimumab, and MTX, respectively). aSimultaneous achievement of DAS28(CRP) < ΔmTSS ≤ HAQ-DI < 0.5. bSimultaneous achievement of DAS28(CRP) < ΔmTSS ≤ HAQ-DI < 0.5. The CDC and CDR population are patients with radiographic data, nonresponder imputation is used if HAQ or DAS data are missing. ADA: adalimumab; MTX: methotrexate; DAS28: 28-joint Disease Activity Score; CRP: C-reactive protein; HAQ-DI: Health Assessment Questionnaire–Disability Index; ΔmTSS: change in modified total Sharp score. Edward C. Keystone et al. J Rheumatol 2014;41:5-14 ©2014 by The Journal of Rheumatology

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