1. Current and Emerging Data in CTEPH

2. Pathophysiology of CTEPH

3. Clinical Classification of Pulmonary Hypertension

4. Key Principles in CTEPH Management

5. Pulmonary Endarterectomy (PEA)

6. Balloon Pulmonary Angioplasty (BPA)

7. Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension (CHEST-1)

8. Riociguat -- Soluble Guanylate Cyclase Stimulator Mechanism of Action

9. CHEST-1*: Mean Change in 6MWD From Baseline

10. CHEST-2 Long-Term Extension Study of Riociguat for CTEPH

11. CHEST-2 Study: AEs

12. Early Access Study (EAS)

13. EAS Study Design

14. EAS Results

15. EAS AEs

16. MERIT-1

17. Macitentan -- MERIT

18. MERIT-1 Safety

19. Conclusions

20. Abbreviations

21. Abbreviations (cont)