1. Welcome to Animal and Veterinary Services
OLA HAWAII Boot Camp 2018
Sylvia kondo, dvm, avs manager & university veterinarian
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2. Objectives 1. (What) Background Information
2. (How) Getting Started Working with Vertebrate Animals
3. (Who) Can Provide Assistance to You
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3. Background Information - AVS
AVS helps oversees the University of Hawaii Animal Care and Use Program 1) providing veterinary oversight for the use of vertebrate animals for research, teaching, and management activities and 2) ensuring the individuals are adequately trained.
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4. Background Information - AVS
AVS also operates the vivariums at Mānoa and Kaka‘ako. In July 2016, JABSOM and UH Cancer Center animal care programs received accreditation by the Association for Assessment and Accreditation for Laboratory Animal Care, International (AAALAC).
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5. Background Information Federal Regulations
U. S. DHHS Public Health Service
Health Research Extension Act of 1985
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6. Background Information Federal Regulations
United States Department of Agriculture
Food Security Act1985
One month after passing the Health
Research Extension Act of 1985
The Animal Welfare Act was amended
In the Food Security Act
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7. Background Information Federal Regulations
The UH must maintain an Assurance of Animal Welfare with the Public Health Service (PHS) that it will conform with the PHS Policy on Humane Care and Use of Laboratory Animals. This allows the UH to receive federal funds for vertebrate animal research, teaching, testing.
The UH must be registered with the USDA, who conduct periodic inspections of the animal facilities to ensure compliance with the Animal Welfare standards, if they use AWA covered species.
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8. Background Information Federal Regulations
It is mandated by the the federal regulations that each institution appoint an Institutional Animal Care and Use Committee (IACUC) to oversee and evaluate the institution’s animal programs, procedures, and facilities.
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9. Background Information Federal Regulations
All vertebrate animal activity must be reviewed and approved by the IACUC prior to start of work. Any revisions to an existing protocol must also receive prior approval. Once a year, the UH IACUC
reviews annual renewals of the protocol
The UH IACUC uses the Topaz® protocol
software.
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10. Background Information Federal Regulations
The IACUC conducts semi-annual inspections of research facilities and evaluates the institution’s program of humane animal care and use.
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11. Background Information Federal Regulations
The IACUC reviews and investigates concerns involving care and use of animals at the institution. They are authorized to suspend previously approved animal activities.
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12. Background Information Federal Regulations
Significant problems with animal care must be reported.
One method of reporting deficiencies is known as the Whistle Blower Policy. These deficiencies can be confidentially reported without fear of discrimination or reprisal. See UH IACUC Policy 7 Reporting Concerns of Animal Misuse or Abuse.
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13. Background Information Federal Regulations
Failure of the University of Hawaii to comply with Federal regulations can result in suspension or loss of contracts and grants involving vertebrate animals, citations and monetary fines, closure of facilities, and negative publicity to the institution.
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14. Getting Started 1. Complete on-line CITI Training
What modules are required by UH IACUC? Visit UH IACUC policy 13 Requirement for Personnel Training CpRof36BRW9KcXRnWTdRbWM/edit
For CITI on-line registration and modules visit
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15. Getting Started
2. Individuals complete protocol-specific training prior to working independently on protocol activities
Demonstration of proficiency for hands on procedures
Standard Operating procedures for chemical and/or potential biological hazards used in animals
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16. Getting Started
3. Individuals requesting access into the vivariums and who work with research animals on an IACUC protocol and/or routinely exposed to animals, animal waste, or animal tissues must enroll in the Occupational Health and Safety Program (OHSP).
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17. Getting Started
3. How to enroll in Occupational Health and Safety Program
a. Complete  OHSP Education
to access training
b. Complete Health History Questionnaire to be reviewed by a Health Professional
Visit health-and-safety-manuals
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18. Getting Started 4. If you are the Principal Investigator on a protocol
Contact an AVS veterinarian when developing protocols that may involve more than momentary pain or distress.
Request Veterinary Care for your protocol activity by completing IACUC Policy 15 Form, found at
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19. Getting Started
5. Complete classroom training required by the Biosafety Program and/or the Environmental Health and Safety Office. Ensure that any permits for importing biological commodities are in place (long lead times).
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20. Getting Started
6. Complete and submit online Topaz IACUC Protocol form
Visit
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21. Getting Started IACUC protocol
Write concisely and at a 12th grade high school lay language.
Avoid cutting and pasting your grant application
Address harm-benefit statement for protocols involving more than momentary pain or distress
Provide a simple chronological sequence of events in experimental design
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22. Getting Started IACUC protocol
Useful links to SOPs and UH IACUC policies to assist you as your write your protocol Visit
guidelines
Useful link for literature data base searches for alternatives
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23. Getting Started IACUC protocol
3 Rʻs
Replacement
Refinement
Reduction
Statistical tests
Previous literature
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24. Getting Started IACUC protocol
Reducing regulatory burden on making some revisions outside of full committee review to a previously approved protocol:
Significant Changes to Previously Approved Protocol
CpRof36BUmIwZW1oZnoyRjg/edit
Designated Member Review
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25. Getting Started IACUC protocol
IACUC Policy 45 for procedures involving research, testing, or instruction conducted with live vertebrate animals and collaborating research institutions and organizations. 
animal-use-activities-collaborating-institutions-and- organizations
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26. Who Can Assist Me? AVS staff
AVS Veterinary Staff (developing IACUC proposals, assistance on protocols, veterinary supply orders, training and documentation of compentencies for procedures using animals)
Dr. Michael Wong, Staff Veterinarian,
AVS Veterinary Assistant
Dr. Sylvia Kondo, University Veterinarian,
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27. Who Can Assist Me? AVS staff
Ms. Diana Talerico, Operations Supervisor, (rodent orders, rodent exports and imports, Occupational Health and Safety education, general vivarium questions/concerns, estimates)
Jeff Hall, (vivarium access requests and orientations)
Ms. Karen Okamura, Fiscal Administrator, (animal orders, estimates, fiscal and billing questions)
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28. Who Can Assist Me? Animal Welfare Compliance Office
Ms. Denise Yee, IACUC Coordinator and Compliance Officer,
Ms. Caryn Hashimoto, Post-Approval Specialist and Compliance Officer,
Mr. Norman Magno, Manager and Compliance Officer, Executive Secretary UH IACUC, Animal Welfare Program
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29. Who Can Assist Me? Biosafety Program (use of biological commodities in animals and in the laboratory)
Mr. Hubert Olipares, Biosafety Officer, Audits and Inspection Specialist,
Mr. Steve Case, Education Coordinator,
Ms. Caryn Hashimoto, IBC Coordinator,
Mr. Norman Magno, Manager and Compliance Officer, Biosafety Program,
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30. Who Can Assist Me? Environmental Health and Safety Office (Use of chemicals and physical hazards in animals and in the laboratory)
Mr. Hans O. Nielson, Occupational Health and Safety Program Manager,
Ms. Lisa Johns, JABSOM EHSO,
Ms. Janet Meeks, JABSOM EHSO,
Mr. Matt Hiramoto, UH Cancer Center EHSO,
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31. Thank you for your time and attention
For more information on AVS please visit
center-services
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