1. Treatment of postherpetic neuralgia: a review of therapeutic options
Charles E. Argoff, MD, Nathaniel Katz, MD, Miroslav Backonja, MD 
Journal of Pain and Symptom Management 
Volume 28, Issue 4, Pages (October 2004)
DOI: /j.jpainsymman
Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

2. Fig. 1
Spontaneous impulses and hyperexcitability in peripheral afferent fibers. After injury of peripheral nociceptive fibers, the tips of the damaged axons begin to regenerate and form numerous “sprouts.” Damaged nerve endings as well as axonal “sprouts” exhibit spontaneous impulses and increased sensitivity to thermal, mechanical, and chemical stimuli. The region of the fiber near the dorsal root ganglion also begins to exhibit spontaneous activity (Figure used with permission from Fields HL, Rowbotham N, Baron R. Postherpetic Neuralgia: Irritable Nociceptors and Deafferentiation. Neurobiology of Disease, 1998; 5: 209–227).
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

3. Fig. 2
a) Following degeneration of primary afferent nociceptive C-fibers (C), neurons located in the substantia gelatinosa (SG) of the spinal cord (shown in the shaded area) suffer a loss of afferent connectivity b) Possibly in response to neurochemical signals released during fiber damage and degeneration, central terminals of surviving afferents (AB) that convey information about non-noxious stimuli and project ventrally form axonal sprouts that travel dorsally and establish aberrant connections with the deafferentiated SG neurons (Figures 2a and 2b used with permission from Fields HL, Rowbotham N, Baron R. Postherpetic Neuralgia: Irritable Nociceptors and Deafferentiation. Neurobiology of Disease, 1998; 5: 209–227).
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

4. Fig. 2
a) Following degeneration of primary afferent nociceptive C-fibers (C), neurons located in the substantia gelatinosa (SG) of the spinal cord (shown in the shaded area) suffer a loss of afferent connectivity b) Possibly in response to neurochemical signals released during fiber damage and degeneration, central terminals of surviving afferents (AB) that convey information about non-noxious stimuli and project ventrally form axonal sprouts that travel dorsally and establish aberrant connections with the deafferentiated SG neurons (Figures 2a and 2b used with permission from Fields HL, Rowbotham N, Baron R. Postherpetic Neuralgia: Irritable Nociceptors and Deafferentiation. Neurobiology of Disease, 1998; 5: 209–227).
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions