1. RSV Takes Control of Neonatal Breg Cells: Two Hands on the Wheel
Peter J.M. Openshaw 
Immunity 
Volume 46, Issue 2, Pages (February 2017)
DOI: /j.immuni
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2. Figure 1 RSV Targets Neonatal Regulatory B Cells
RSV fusion protein engages polyreactive IgM on neonatal regulatory B (nBreg) cells. This causes increased expression of CX3CR1, which is also expressed on resting ciliated respiratory epithelial cells and monocytes. CX3CR1 is the natural ligand for fractalkine (CX3CL1), but also binds the RSV attachment protein G. This engagement leads to non-lytic infection of nBreg cells, cell activation, and IL-10 production.
Immunity  , DOI: ( /j.immuni )
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