1. Fertility Center
A HURDLE IN THE EGG FREEZING RACE: COMPARISON OF DONOR AND AUTOLOGOUS OOCYTE CRYOPRESERVATION (OC) OUTCOMES
Sarah Druckenmiller, Patty Ann Labella,
Shannon DeVore, James Grifo,
Brooke Hodes-Wertz, Nicole Noyes

2. OBJECTIVE
Oocyte cryopreservation is now a mainstream fertility preservation option
Minimal outcome data is available
Much of our knowledge is based on donor oocyte cryopreservation, which may be superior to autologous oocyte cryopreservation
Aim: to compare donor and autologous oocyte cryopreservation thaw outcomes
Retrospective cohort study
Reviewed all donor and autologous oocyte cryopreservation thaw cycles from October 2004 – January 2017 at our large university-based fertility center
Fertility Center

3. RESULTS DONOR OOCYTE CRYOPRESERVATION (n=110 recipients)
ALL AUTOLOGOUS OOCYTE CRYOPRESERVATION
(n=123 patients)
AUTOLOGOUS OOCYTE CRYOPRESERVATION <35y (n=23 patients)
Younger
(median 26y, range 21-31y)
Older
(median 38y, range 25-42y)
(median 33y, range 25-33y)
Fewer MIIs thawed
(median 8)
More MIIs thawed
(median 11)
(median 13)
Significantly higher:
Oocyte survival (88%)
2-PN fertilization (67%)
Blastocyst formation (49%)
Significantly lower:
Oocyte survival (78%)
2-PN fertilization (53%)
Blastocyst formation (27%)
Oocyte survival (79%)
2-PN fertilization (60%)
Blastocyst formation (36%)
Significantly fewer thaw cycles with NO transfer (7%)
Significantly more thaw cycles with NO transfer (34%)
Significantly more thaw cycles with NO transfer (33%)
Live birth rate for all transfers: 53%
Live birth rate for all transfers: 41%
Live birth rate for all transfers: 56%
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4. CONCLUSIONS
As women increasingly rely on autologous oocyte cryopreservation for fertility preservation, it is critical to provide realistic expectations about outcomes
Developmental parameters for autologous oocyte cryopreservation were inferior to donor oocyte cryopreservation, resulting in:
Production of fewer blastocysts
Higher proportion of patients with no embryos for transfer
In those achieving embryo transfer, live birth outcomes in autologous vs. donor oocyte cryopreservation cycles appear comparable
Donor oocyte thaw data is not an appropriate counselling tool for women pursuing autologous oocyte cryopreservation  only autologous thaw data should be used
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