1. Impact of JPIAMR funded projects: Strategy development
Shawon Lahiri
MB meeting October, 2018
Leuven

2. The volume of work accomplished by the project Benefits or changes
Calls conducted
Projects funded
What the projects do to fulfill its mission
The volume of work accomplished by the project
Benefits or changes
for partcipants during or after project activities
Increased skills, collaborations, Training and mobility
The long-term consequences
A fundamental
CHANGE
Intended or unintended in a system or society
Both quantity and quality
Publications, Products and Interventions

3. Overview of JPIAMR funded projects and networks
Total investment of ~67 M €
8 Joint transnational calls
70 projects supported

4. Interventions (One Health)
Overview of the Joint Transnational Calls Supported by JPIAMR
Year
Funding scheme
Call Name
Priority topics
Supported
projects
partners
Total investment
(M €)
2014
Projects
InnovaResistance
Therapeutics 7 41
8,1
2015
Repurposing Neglected Antibiotics 3 17
4,5
2016
Transmission and Selection of Resistance in Humans, Animals, and the Environment (ERAnet Cofund)
Transmission
(One Health) 19 96
28,2
Networks
AMR Networks
All  13
160
0,65
2017
Comparison of prevention, control and intervention strategies for AMR infections through multidisciplinary studies, including One Health approaches
Interventions (One Health) 10 47
11,5
2018
Therapeutics: New targets, compounds and tools 42
11,8
Surveillance
Ongoing
1,1
Building the Foundation of the JPIAMR Virtual Research Institute
 All 8 -
0,5
Total 70
201
66,35 (M €)

5. JPIAMR Transnational projects
2014
InnovaResistance
7 projects
41 partners
8,1 M €
2015
Repurposing Neglected Antibiotics
3 projects
17 partners
4,5 M €
2016
Transmission Dynamics
19 projects
96 partners
28,2 M €
2017
Prevention and Intervention
10 projects
47 partners
11,5 M €
2018
New targets, compounds and tools
42 partners
11,8 M €
JPIAMR Transnational projects

6. JPIAMR Transnational projects

7. JPIAMR Transnational Networks
2016
AMR Networks
13 networks
160 partners
0,65 M €
2018
Surveillance Network
Ongoing
1,1 M €
Building the Foundation of the JPIAMR-VRI
8 networks
0,5 M €

8. Overview of JPIAMR funded projects in Transmission
~28,2 M € invested in therapeutics related projects
19 research projects supported
96 researchers from 17 different countries

9. JPIAMR funded 19 projects in Transmission research
Distribution of JPIAMR funded projects on the basis of pathogens investigated
JPIAMR supported research projects addressing pathogens categorized under WHO Priority Pathogens List
WHO priority pathogens
Medium (Priority 3)
Critical (Priority 1)
High (Priority 2)
Others

10. Showcase: JPIAMR supported network related to Transmission and Environment
Modes of bacterial transmission between humans and animals through ‘filth flies’.
Flies (Diptera: Muscidae) and the spread of antimicrobial resistant bacteria – JPIAMR supported network
Travel Medicine and Infectious Disease 22 (2018) 8–17

11. Projects on Environment
Overview of JPIAMR funded projects and networks in Environment
14 projects on Environment
Out of which 4 are related to water
Projects on Environment
~19 M€ invested in Environment projects
Of which ~7.5 M€ invested in water related projects
Investments
Keywords from JPIAMR supported projects in Environment

12. Showcase: JPIAMR supported projects related to Environment and Water
Antibiotic Resistance in Wastewater: Transmission Risks for Employees and Residents around Waste Water Treatment Plants (AWARE-WWTP)
To assess carriage of extended-spectrum betalactamase (ESBL) and carbapenemase-producing Enterobacteriaceae and resistance genes in WWTP workers, in residents in the proximity of treatment plants, and in water and air samples – both in countries with low and high antimicrobial resistance (AMR).
Gene-gas: Wastewater treatment plants as critical reservoirs for resistance genes
Schematic representation of the proposed project.
Resistance genes from both bacteria and bacteriophages will be monitored in wastewater treatment plants
Novel means will be developed to reduce the “survival” of the genes in WWTP, reducing the spread of resistance genes through
transformation and transduction.
Finally, a mathematical model to predict spreading of resistance genes in WWTP, and the impact of novel treatments, will be developed.

13. Overview of JPIAMR funded projects in Therapeutics
~24,4 M € invested in therapeutics related projects
20 research projects supported
100 researchers from 17 different countries
In pipeline
12 novel candidates
and
8 projects on alternative approaches

14. JPIAMR funded 20 projects in Therapeutics research
Distribution of JPIAMR funded projects on the basis of pathogens studied
JPIAMR supported research projects addressing pathogens categorized under WHO Priority Pathogens List
WHO priority pathogens
Medium (Priority 3)
Critical (Priority 1)
High (Priority 2) TB
Others
Majority of the projects involve Critical (Priority 1) pathogens
A fair distribution of projects investigating other priority pathogens as well

15. JPIAMR invest in new drugs and alternative approaches
Classification of the projects on the basis of their aims
Ribosome-targeting antibiotics
Plant extracts
Mycobacterial Tolerance Inhibitors
CRISPER/Cas
(phage therapy)
Virulence secretion system Inhibitors
Nanoparticles
Peptide Nucleic Acids
Inhibitors for Metallo-Beta-Lactamase (MBL)
Biofilm-targeting phage therapy
Optimizing the structure of previously identified MBL inhibitors
Novel candidate/
strategies
Alternative approaches
Efflux pumps blockers
Secondary metabolites
Drugable
sites in trans-peptidases
Combination of Neglected and Disused Antibiotics (ND-AB)
Biofilm-disrupting agents
Flavodoxin inhibitor antibiotics
Siderophore conjugated antibiotics
Combination of ND-AB with immuno- stimulatory drugs
Thiamine pyro-phosphate
riboswitch inhibitors
Antibiotics targeting persisters
WHO priority pathogens
Critical (Priority 1)
High (Priority 2)
Critical/ Mycobacterium tuberculosis
Medium (Priority 3)
All pathogens

16. Digital communication
Strategic approach – trial
Engage the researchers (clear communication)
Provide a template structure (easier to engage)
Data representation
Digital communication

17. Strategic approach – trial

18. Publication metrics Publications for different research categories
Citations per publication
Number of publications JPIAMR has been mentioned
Publications for different research categories

19. Publication metrics

21. Thank you!
@JPIonAMR