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Current Effectiveness and Risks of Isolated Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy  Nicholas G. Smedira, MD, Bruce W. Lytle, MD,

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Presentation on theme: "Current Effectiveness and Risks of Isolated Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy  Nicholas G. Smedira, MD, Bruce W. Lytle, MD,"— Presentation transcript:

1 Current Effectiveness and Risks of Isolated Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy  Nicholas G. Smedira, MD, Bruce W. Lytle, MD, Harry M. Lever, MD, Jeevanantham Rajeswaran, MS, Gita Krishnaswamy, MS, Ryan K. Kaple, BS, Diana O.W. Dolney, MSN, RN, Eugene H. Blackstone, MD  The Annals of Thoracic Surgery  Volume 85, Issue 1, Pages (January 2008) DOI: /j.athoracsur Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Extended myectomy. Muscle resection begins well below the membranous septum (oval), removing muscle over both papillary muscles, and often extending to both trigones. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Effectiveness of septal myectomy as assessed longitudinally by echocardiography after isolated septal myectomy. Dot at vertical axis is preoperative value, and dashed line leads to intermediate postmyectomy value at time zero. Dots are grouped “independent” point estimates, and solid line enclosed within 68% confidence limits (equivalent to ±1 standard error) is average response corrected for repeated measures. (A) Thickness of interventricular septum. (B) Peak left ventricular outflow tract (LVOT) gradient. (C) Anterior motion of septal leaflet of mitral valve (SAM). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 New York Heart Association (NYHA) functional class after isolated septal myectomy. Symbols represent grouped “independent” distributions of classes and solid lines are estimated prevalence of repeated measures. Class I is represented by closed circles, class II by open circles, class III by squares, and class IV by triangles. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Freedom from reoperation related to hypertrophic obstructive cardiomyopathy after isolated myectomy. Solid lines are estimated prevalence of repeated measures. Open circles represent individual reoperations. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Freedom from pacemaker insertion after isolated septal myectomy (patients with pacemakers preoperatively excluded). Solid lines are estimated prevalence of repeated measures. Open circles represent individual pacemaker insertion. (PPM = permanent pacemaker.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Survival after isolated septal myectomy. Solid lines are estimated prevalence of repeated measures. Open circles represent individual deaths. The dash-dot-dash line is survival of an age-, race-, gender-matched U.S. population life table. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions


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