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Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome  Sigrun B. Kjøtrød, M.D., Arne.

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Presentation on theme: "Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome  Sigrun B. Kjøtrød, M.D., Arne."— Presentation transcript:

1 Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome  Sigrun B. Kjøtrød, M.D., Arne Sunde, Ph.D., Vidar von Düring, M.D., Sven M. Carlsen, M.D., Ph.D.  Fertility and Sterility  Volume 91, Issue 2, Pages (February 2009) DOI: /j.fertnstert Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Randomized women with five complete serum samples during the whole IVF procedure. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Androgen levels during IVF treatment.
Patients with complete samples (N = 57). Differences between metformin and placebo group are given directly with P values in figure. Differences within groups:a P≤.001b P≤.01c P<.05 Start downregulation = after 12–14 weeks pretreatment, and ≤ 5 days before GnRH analogue. Start stimulation = ≤ 1 day before starting rFSH. Before hCG = the same day as and before hCG injection. Before OPU = the same day as and before ovum pick-up. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions


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